منابع مشابه
O55:H7 Diversity Refines O157 Evolutionary Model
18 a Present address: Eureka Genomics, 750 Alfred Nobel Drive, Hercules, CA, 94547 19 b Present address: Wafergen Biosystems, 7400 Paseo Padre Parkway, Fremont, CA 94555 20 c Present address: Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 21 d Present address: 12170 Calle Uvas, Gilroy, CA, 95020 22 e Present address: 3180 Melendy Drive, San Carlos, CA, 94070 23 Copyright © 2012, Ameri...
متن کاملEtiologic Factors in SLE
We are currently witnessing an explosion of information about the genetic contribution to complex human diseases such as systemic lupus erythematosus (SLE). These genetic discoveries have profound implications for efforts to more fully characterize etiologic pathways and mechanisms. Further, these etiologic insights should lead to improved diagnostic and prognostic tools and inform the developm...
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B cells are essential to the development of systemic lupus erythematosus (SLE). The chimeric monoclonal antibody rituximab depletes B cells by targeting the pan-B-cell surface marker CD20. Preliminary experience with this agent in SLE and other autoimmune diseases has been encouraging. Controlled trials in SLE will be necessary to determine whether rituximab is useful therapy in this disease, a...
متن کاملEpigenetics in SLE
PURPOSE OF REVIEW Systemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition is essential for disease expression, risk alleles in single genes are usually insufficient to confer disease. Epigenetic dysregulation has been suggested as the missing link between genetic risk and the development of clinically evident disease. ...
متن کاملKey autoantigens in SLE.
Murine and human systemic lupus erythematosus (SLE, lupus) is characterized by the appearance of autoantibodies directed to nuclear and cell membrane phospholipid components. Some functionally related nucleic acid-containing macromolecules such as chromatin or ribonucleoprotein particles are specifically targeted both by autoantibodies and T cells involved in lupus pathogenesis. In the last dec...
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ژورنال
عنوان ژورنال: Indian Journal of Rheumatology
سال: 2008
ISSN: 0973-3698
DOI: 10.1016/s0973-3698(10)60429-3